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Description

The bulk of this evidence is pre-clinical

It has been suggested that, when using rodent models of ASD, approximately 1520 animals per genotype, treatment, and sex are required to ensure adequate power and reliability of behavioral outcomes [102]

Spermidine/spermine N1-acetyltransferase 1 (SAT1), which is critical for cell polyamine catabolism mediated through acetylation, is also a target gene of p53 (Fig