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This fibrosis stiffens the heart muscle, reducing its ability to contract and relax effectively, further impairing cardiac function [89]

The majority of SLC16 proteins usually catalyze proton-linked transport of monocarboxylate substrates like lactic acid and pyruvic acid, while some members recognize aromatic amino acids and thyroid hormone (Halestrap and Wilson, 2012

Peroxidase Activity In the cells, hydroperoxides are reduced by several families of enzymes, in particular thiol peroxidases including the peroxiredoxin (PRX) and glutathione peroxidase-like protein (GPXL) families (Rouhier and Jacquot, 2005)