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Other groups at risk of inadequate vitamin B12 intake or absorption include: Strict vegetarians and vegans People who have had stomach stapling or weight loss surgery People with Celiac or Crohns disease People who frequently use prescription drugs to control heartburn People with autoimmune diseases People who smoke People who consume a lot of alcohol People who have used a lot of antibiotics Some people might not consume enough vitamin B12 rich foods, and others cant absorb enough B12 through their diets no matter how much they take in if without intrinsic factors

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Quality of evidence was graded following the Grading of Recommendations Assessment, Development and Evaluation

Therefore, the antioxidant effect of berberine has great effects on the treatment of neurodegenerative diseases