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Intrinsic mechanisms refer to the different structural features of the isoforms at the gene, transcript, or protein level, while context-dependent mechanisms describe specific functions mediated by the cellular context such as cell-specific regulation of FOXO isoforms expression, cell-specific binding partners and cell-specific post-translational modifications (PTMs)

Cagrilintide is a long-acting, acylated amylin analogue developed for the treatment of obesity and metabolic disorders

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This uncertainty can prolong approval timelines and create additional hurdles for researchers and developers