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While the underlying mechanism of MTHFR independent global DNA methylation remains unknown, the MTHFR polymorphisms related gene-specific DNA methylations were commonly reported in various pathological conditions

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S., Cyrne, L

This places GHK-Cu in the category of a supportive adjunct: something you might layer into a topical protocol for scalp health, anti-inflammation, and perhaps a modest boost in local 5AR1 inhibition not a replacement for pharmaceutical inhibitors