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People with too little copper may need chronic treatment

While more research is needed specifically in dogs, these cardiovascular benefits are in line with the benefits of quercetin that have been firmly established in studies in humans

Gene Volume 554(2):148154

Therefore, blood pressure lowering NHE3 inhibition could therefore be considered as a therapeutic target for hypertension, although more animal and human studies are needed to confirm that NHE3 inhibition is a treatment option, as some reports suggest that NHE3 deficiency can cause irritable bowel disease-like symptoms, gut dysbiosis, and an inflammatory immune system (Laubitz et al., 2016