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When NNMT activity is high, less nicotinamide is available for NAD+ synthesis

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Key questions including the existence of lactyl-CoA in vivo, the physiological relevance of non-enzymatic lactylation, and the identification of specific reader proteins must be resolved before lactylation can be fully established as a stable and universal regulatory mechanism

Figures Abstract Background Glutathione S-transferases (GSTs) are known to abolish or reduce the activities of intracellular enzymes that help detoxify environmental carcinogens, such as those found in tobacco smoke