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NCT04449029) 1485-C RECOMBINANT MOSAIC HBV CAPSID PARTICLES FOSTER ADAPTIVE IMMUNITY AGAINST THE MOST PREVALENT HBV GENOTYPES BY THERAPEUTIC VACCINATION Shubhankar Ambike 1 , Julia Sacherl 1 , Alexander Seidler 1 , Arie Geerlof 2 , Anna Kosinska 1,3 , Sophia Schreiber 1 , Frank Thiele 1 , Tanja Bauer 1,3 , Michael Nassal 4 , Anne Schtz 5 and Ulrike Protzer 3 , (1)Institute of Virology, School of Medicine, Technical University of Munich and Helmholtz Munich, Germany, (2)Institute of Structural Biolology, Helmholtz Munich and Technical University of Munich, Germany, (3)German Center for Infection Research, Munich Partner Site, Germany, (4)University Hospital Freiburg, Internal Medicine 2/Molecular Biology, University of Freiburg, Germany, (5)Faculty of Chemistry and Pharmacy, Ludwig Maximilian University of Munich, Germany Background: Hepatitis B virus (HBV)-specific B- and T-cell responses are key to cure HBV

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These potential benefits include preserved eGFR, reversal of bone-mineral disorder, decreased risk of progression to dialysis, reduced urinary protein loss, decreased blood phosphate, and reduced all-cause mortality