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The MHRA has issued clear guidance on the risks associated with unlicensed medicines and research chemicals being marketed for weight loss or body composition purposes

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(Biochem Pharmacol 2018) documented a reduction of -35% in white adipose tissue, -40% in adipocyte volume, -5.1% in body weight and -30% in plasma cholesterol in just 11 days in obese mice (DIO), without any change in food intake

This is metabolically significant because visceral adipose tissue is strongly associated with metabolic dysfunction, insulin resistance, cardiovascular disease risk, and systemic inflammation