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Lack of energy Shortness of breath Memory loss, difficulty in concentrating, and cognitive difficulties Muscle cramps Noticeable heartbeats (palpitations) Irritability and possible signs of mental health disorders such as depression Headaches A sore and red tongue (glossitis) Disturbed vision Vitamin B12 can also help reduce stress in the body

Other factors that can cause acne include hormonal changes, certain medications, diet, stress, and certain diseases

ROS cause lipid peroxidation, protein oxidation, and mitochondrial DNA damage, leading to neuronal apoptosis and synaptic dysfunction (Simunkova et al., 2019)

Thus, the field of nootropics is largely driven by extrapolative findings rather than robust direct evidence, and should be considered in this light