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The discrepancy may be attributed to the distinct metabolic characteristics of cells and the variations in the induction approaches used in different studies 18,23

Indeed, decreased insulin sensitivity and impaired glucose metabolism systemically are linked to the progression of neurodegenerative diseases (Farooqui et al., 2012)

Haruwaka K, Ikegami A, Tachibana Y, Ohno N, Konishi H, Hashimoto A et al (2019) Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

Interlink between the gut microbiota and inflammation in the context of oxidative stress in Alzheimers disease progression