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Abstract Diminished growth factor signaling improves longevity in laboratory models, while a reduction in the somatotropic axis is favorably linked to human aging and longevity

The former could be caused by elevated norepinephrine, as catechol-O-methyltransferase (COMT) degrades monoamines (Hall et al., 2019)

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Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study