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607 Clausenamide, an alkaloid isolated from Clausena lansium , interacts directly with Ser663 of ALOX5, blocking the nuclear translocation of ALOX5, alleviating lipid peroxide accumulation and ferroptosis in dopaminergic neurons, significantly improving behavioral deficits in PD mouse models, and providing an attractive strategy for PD treatment

This creates a challenging paradox for patients with ME/CFS and Long COVID: when mitochondria are damaged and ATP production drops, the cell lacks the energy required to synthesize new glutathione

Matsuzawa, D

While glutathione itself is not typically linked to hair loss , excessive supplementation or imbalances can contribute to temporary hair thinning