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2-methoxyestradiol (2-ME), a metabolite of 17--estradiol synthesized by Catechol-O-Methyltransferase (COMT), induces the differentiation of the endovascular cytotrophoblast cells into its invasive phenotype under the condition of hypoxia (75)

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Knee osteoarthritis has doubled in prevalence since the mid-20th century

Of solved structures, all GS enzymes have a composite active site with residues contributed from two adjacent protomers