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Despite its beneficial roles, excessive production of NO can lead to its reaction with superoxide to form peroxynitrite (ONOO ), a potent oxidizing and nitrating agent [31]

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Jabbour EJ, Short NJ, Huang X, Maiti A, Kadia TM, Daver N, Borthakur G , DiNardo CD, Pemmaraju N, Sasaki K, Estrov Z, Verstovsek S, Ravandi F, Alvarado Y, Sekeres MA, Komrokji RS, Steensma DP, DeZern AE, Roboz GJ, Miller D, Dong X, Kantarjian HM, Garcia-Manero G