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J Clin Oncol 30 (2): 134-41, 2012

Discussion Nutrient limitation or starvation is a frequent feature of the cellular microenvironment in the core of aggressive solid tumors

However, it is crucial to establish a proper balance between copper metabolism and therapeutic interventions in order to elicit desirable performance while minimizing the toxicities and side effects

Concentration calculations depend directly on the diluent volume used, and researchers should maintain consistent reconstitution protocols across a study to preserve comparability between samples