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doi: 10.1002/rmv.2403 418 AlkafaasSSAbdallahAMHussienAMBedairHAbdoMGhoshSet al

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In PCOS granulosa cells, elevated phosphorylation of the pro-apoptotic protein BAX, coupled with suppressed phosphorylation of the anti-apoptotic protein BCL-2, enhances mitochondrial pathway apoptosis, accelerating follicular atresia ( 3.6 Chronic low-grade inflammation Chronic low-grade inflammation have been identified as a central component in the pathogenesis of PCOS, rather than mere accompanying phenomena

Amylin restrains this pathological postprandial glucagon secretion, and it does so most powerfully in the fed state, reducing inappropriate hepatic glucose output