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Have certain chronic conditions, including diabetes, obesity and heart or kidney disease

Unfolded protein response (UPR) is an adaptive response of the ER to maintain homeostasis (68)

FADD flox/flox Organs were dissected as indicated in each experiment and infused with 4% (vol/vol) neutral-buffered formaldehyde, fixated for 48 h, dehydrated in a graded ethanol series and xylene, and finally embedded in paraffin

Although the mechanism through which vitamin C delays AD progression is not properly described, vitamin C supplementation is involved in the proteolytic processing of APP and leads to a decrease in the A peptides along with a substantial reduction of lysosomal enzymes in sporadic AD as shown by the effects of supplementing 50uM vitamin C to skin fibroblasts of AD patients ( via modulation of oxidative stress mechanism contributing toward impaired cognition ( Evaluation of nutrient intake of elderly community-dwelling AD patients showed poor dietary intakes associated with significant differences in levels of macronutrients, energy, zinc, calcium, iron, etc., (Shatenstein et al., 2007)