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Compared to NZW mice, the expression of the transferrin receptor 24p3R in the renal tubules of NZB/W mice was reduced, while transferrin expression and ferritin expression were increased, consistent with increased iron accumulation and compensatory downregulation of uptake pathways

The body can use it immediately upon absorption to support essential physiological processes

More recently, two studies from the Spielmann laboratory using genetic and proximity ligation approaches have shed further light on this process, revealing that components of a non-canonical endocytic apparatus are involved

Mice were handled in accordance with the NIH Guide for the Care and Use of Laboratory Animals, and experiments were approved by the Fred Hutch Cancer Center Institutional Animal Care and Use Committee and Institutional Review Boards