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Supporting this, we found that, as in TLR3 signalling, the absence of OPTN strongly impaired STING-induced activation of TBK1 and IRF3, whereas co-deletion of TANK, NAP1 and SINTBAD did not (Fig

doi: 10.1111/ijfs.13773 30

Apc-mutated intestinal tumors lacking Stard7 are sensitive to mTORC1 inhibition Given the fact that intestinal tumors arising from constitutive Wnt signaling and lacking Stard7 show enhanced mTORC1 signaling, we hypothesized that these malignancies would be very sensitive to mTORC1 pharmacological inhibition