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Int J Mol Sci (2019) 20:904

S.Al-EmranM

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Accessory proteins such as zonula occludens (ZO)-1, ZO-2, AF-6, 7H6, and cingulin function as essential molecular bridges connecting transmembrane tight junction proteins to the intracellular actin cytoskeleton, thereby playing a critical role in preserving the structural and functional integrity of tight junctions (148)