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Front Endocrinol (Lausanne) (2022) 13:791860

Theoretically yes, since their mechanisms dont overlap 5-Amino-1MQ targets cellular NAD+ metabolism peripherally while tesofensine acts centrally on appetite circuits

Hydration and Hangover Prevention: Replenishing Fluids: Adequate hydration, both during and after alcohol consumption, plays a vital role in preventing or alleviating hangover symptoms