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Annu Rev Earth Planet Sci 49:495

34 As such, it could be that FAE has a protective effect against malignancies, though this has yet to be tested

The Limitations of NAD Therapy While there is no dispute about the benefits of NAD+ as an essential coenzyme, the lack of clinical evidence indicates that supplementing declining NAD+ levels with NAD+ does not actually lead to a lasting improvement in NAD+