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1 The ESC also suggests that pioglitazone should be considered for reducing ASCVD risk in patients with T2D with ASCVD based on the data and net benefit-risk assessment

[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Olney DK, Pedehombga A, Ruel MT, Dillon A

Hu B, Ma K, Wang W, Han Z, Chi M, Nasser MI, et al

3.2.1 Metformin 3.2.1.1 Basic science research Despite metformin being the most widely prescribed drug for the treatment of T2DM and being considered an essential medicine by the World Health Organization, its exact mechanism of action is still debated