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Initially, iron overload from transfusions accumulates in the spleen

However, the tree was grown only as a novelty and the fruit was little utilized until the first grapefruit nursery was established in Florida, in 1870

Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025