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In a similar study, combined effect of lycopene, vitamin C, flavonoids and phytosterols was established in the regression of aerodigestive tract carcinoma (Stefani et al., 2000[109])

Moreover, structural superposition between GSH-bound OsDHAR and glutathione disulphide (GSSG)-bound hGSTO1-1 showed dramatic helix (5, 6 and 9) movement in the C-terminal domain region of OsDHAR, which likely allows bound GSH molecules in the G- and H-sites to be sufficient close for GSSG formation (Supplemental Fig