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Complement activation in patients with probable systemic lupus erythematosus and ability to predict progression to american college of rheumatology-classified systemic lupus erythematosus

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PYC modulated cytokine secretion by decreasing in T-helper (Th)1 cytokine levels and increasing Th2 cytokine levels and partially recovered T- and B-cell dysfunction in a mouse model ( In a murine model, PYC demonstrated neuroprotective effects following traumatic brain injury, characterized by a reduction in the proinflammatory cytokines IL-6 and TNF- (Scheff et al., 2013)