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Thus, adequate folate intake is essential for preventing depression, due to its role in the synthesis of dopamine and serotonin, as well as dementia, through the prevention of neuronal damage ( 7 Vitamin B12 Vitamin B12, also known as cobalamin, plays a crucial role in the biochemistry of the nervous system, contributing to essential processes such as the synthesis of DNA, S-adenosylmethionine (SAM), and succinyl-CoA, all of which support nerve cell function and overall neurological health (70, 71)

J Immunol (2020) 205(3):789800

This is why precursors like levodopa are used which can cross the BBB and are metabolized and converted into dopamine in the brain