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NPJ Aging Mech Dis 3:14 Bartke A (2019) Growth hormone and aging: updated review

!DANGEROUS combination

The broader preclinical record, reviewed exhaustively by Graf and Kastin [4, 5], includes sleep-architecture effects in rats and mice, and predominantly REM-related effects in cats a species-specificity that the delta sleep-inducing name does not capture

These anomalies were associated with significant increases in 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), and iron in the midbrain of the A53T mice (Figure 1, DF)