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DNA damage was assessed by the parameter % DNA in tail (100% of cell fluorescence intensity minus intensity of the head % DNA)

OA is characterized by progressive loss of cartilage extracellular matrix (ECM) and pathological changes in other joint tissues such as subchondral bone sclerosis, osteophyte formation, and synovial inflammation 31

10.1016/S0140-6736(17)31472-1 104 MeijerA

Alpha-Lipoic Acid as an Antioxidant Among antioxidant substances, alpha-lipoic acid is unique as it maintains protective functions in both its oxidized (ALA) and reduced (DHLA) forms (Table 1) [8,10], although the latter is more effective in performing antioxidant functions