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population over the age of 12 use antidepressants, most of which are believed to be SSRIs.42 The contraindications (e.g., SSRI use), efficacy constraints, and adverse effects of MB present a need for alternative therapies

The papillary dermis, where collagen-producing fibroblasts begin to be engaged by controlled micro-injury, starts at roughly 0.1 mm and extends down to about 0.5 mm

Further studies indicate that TA-III causes mitochondrial damage and excessive ROS production by increasing intracellular fat phagocytosis and promoting the production of free fatty acids (FFA), which eventually lead to cell damage and even death