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This weight gain effect is related to the increase in GH levels but may also be linked to the appetite-stimulating impact of ghrelin receptor activation [14]

doi: 10.3389/fmicb.2021.772420 90 LimC

When p53 transcriptional activity in response to 5-FU treatment was measured, the mRNA and protein levels of p21, which is a p53 target gene, were decreased in the GST WT -p53-expressing cells