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Additionally, certain medicationslike proton pump inhibitors (PPIs) and metformincan affect B12 absorption if not spaced out appropriately

The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)

I know some recommend just Vitamin B12 as often as every other day, because it can help stimulate the appetite

When B12 levels are suboptimal, your metabolism and energy cycles can suffer making it harder to stay active, recover from workouts, or sustain an effective weight-loss program