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Numerous studies on the major alkaloid, mitragynine, and the less abundant constituent, 7-hydroxymitragynine, of kratom have demonstrated the high binding affinity for supraspinal - and -opioid receptors governing the antinociceptive and antitussive actions of these constituents and their rewarding properties (Thongpradichote et al., 1998

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After 18 months of treatment, the patient's cognitive function test scores improved from 2/12 in the average category at baseline to 7/12 in the average category, demonstrating substantial cognitive enhancement