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Vitamin B12 shots are administered most often in those with genetic conditions that block absorption and people with the disorder called pernicious anemia, which can result in severe malabsorption and deficiency

Thus, therapies that target the CXCL12/CXCR4 and HIF pathways, as well as Treg, may be advantageous for this subset of breast tumors that are less likely to respond to standard chemotherapy