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(2016) Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial

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The cell-surface transmembrane E3 ubiquitin ligases Zinc and Ring Finger 3 (ZNRF3) and Ring Finger Protein 43 (RNF43) act as negative feedback regulators of Wnt/-catenin signaling by inducing the degradation of FZD and LRP6 in a DVL-dependent manner, and R-spondin (RSPO) ligand binding to leucine-rich repeat-containing G protein-coupled receptor (LGR) 4/5 receptors can clear ZNRF3 and RNF43 to strengthen Wnt/-catenin signaling

Conclusion: Utilizing an algorithm to identify TG individuals in US claims data provides insight into a population of TG individuals who have not previously been well described