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1 Introduction Atherosclerosis is a chronic vascular disease characterized by lipid deposition and fibrous tissue proliferation in the arterial wall, and it serves as the primary pathological foundation for cardiovascular diseases (CVDs) ( Classic cell death pathways, including necrosis, apoptosis, and autophagy, contribute significantly to the pathogenesis of atherosclerosis by expanding the necrotic core and releasing pro-inflammatory cytokines ( Among the regulatory factors of ferroptosis, heme oxygenase-1 (HO-1) has recently emerged as a key player, garnering significant attention ( This review will explore the dual role of HO-1 in ferroptosis within atherosclerosis, with an emphasis on its involvement in iron metabolism, oxidative stress, and plaque stability

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doi: 10.1073/pnas.0911378107 9 ShevtsovMSatoHMulthoffGShibataA

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