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In a physiological state, PERK, IRE1, and ATF6 are non-covalently bonded to glucose-regulated protein 78 (GRP78)

doi: 10.1016/j.mam.2008.08.006 8

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As a core energy and biosynthetic substrate for tumor cells, Gln metabolic reprogramming has emerged as a research hotspot in tumor metabolism in recent years