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Description

This process is mediated primarily by mitochondrial fusion proteins such as optic atrophy 1 (OPA1), mitofusin1 (Mfn1) and mitofusin2 (Mfn2) (Hu et al., 2021)

( e ) Schematic of AKP organoid isolation and culture (3D and 2D cell line) with representative images of 3D or 2D cultures treated 5FU at 72 h

The active compound responsible turned out to be a small peptide

In advanced cellular assays, this has been shown to increase mitochondrial biogenesis and enhance the sirtuin-mediated stress response, as documented in prominent metabolic research databases