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Chrysin selectively downregulates MMP-10, demonstrating potent anti-metastatic effects in triple-negative breast cancer (TNBC) models (Monsef-Esfahani et al., 2014) Nepitrin, even at low concentrations, directly inhibits the enzymatic activity of MMP-2 and MMP-9, thereby attenuating proteolytic ECM remodeling (Yao et al., 2019), while luteolin suppresses MMP-2/9 expression to impair migration and invasion of cells of colorectal cancer and breast cancer (Li et al., 2015)

Similar to other periodic disorders, such as migraine, CVS might be characterized by a specific-individual attack threshold above which the synergistic action of the different pathophysiologic mechanisms induces the distinctive clinical expression

Two-tailed students t-test

This makes it water-soluble, allowing it to be excreted in bile