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99% purity verified by third-party HPLC-MS testing

Elderly people due to impaired intestinal absorption and children, premenopausal women, and pregnant women whose diets are low in animal foods are all at increased risk

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines (Higgins and Green, 2008)

Adequate B12 status is necessary for normal cellular function, but supraphysiological dosesbeyond correcting deficiencydo not demonstrably enhance metabolism in individuals with normal B12 levels