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You may consider clinical assessment if: Pigmentation is long-standing or resistant to topical care Melasma remains persistent despite conservative management Post-inflammatory hyperpigmentation does not gradually fade Sun damage is extensive Treatment recommendations should always be individualised after medical evaluation

These drugs predicted by the consensus models were also found essential throughout at least 50% of the sample-specific models, suggesting that these are likely to have an impact on broad melanoma backgrounds (Supplementary Figs

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[DOI] [PubMed] [Google Scholar] [159].Suzuki K, Koike H, Matsui H, Ono Y, Hasumi M, Nakazato H, Okugi H, Sekine Y, Oki K, Ito K, Yamamoto T, Fukabori Y, Kurokawa K, Yamanaka H, Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3