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This has implications in blast induced TBI in a battle field setting

Peptides containing methionine, cysteine, tryptophan, or asparagine residues tend to degrade faster in solution

Essentially, the toxins found in cigarette smoke cause the increased production of free radicals that attach themselves to lung cells and cause their damage or death, according to a study published in 2008 in the American Journal of Respiratory and Critical Care Medicine

Furthermore, in light of increasing tumor resistance, it may prove more beneficial to use combination therapies or block multiple metabolic pathways simultaneously rather than relying on a single agent [176]