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Description

Both forms share dysregulation of the mTORC1 pathway due to loss of TSC gene function, leading to uncontrolled cell growth and infiltration

CRISPR/Cas9-mediated vimentin knockout (VIM KO) in THP-1 macrophages resulted in an inability to form DLPs-equipped macrophages, characterized instead by the continuous initiation of bleb-like growth cones (Fig