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In addition to ESCs, cardiac progenitor cells (CPCs) from diabetic patients have been shown to exhibit decrease enzymatic activity of not only G6PD, but also transketolase (TKT) another NRF2 target gene (Agyeman et al., 2012), resulting in ROS production and apoptosis (Katare et al., 2013)

Understanding Insulin-like Growth Factor-1 Insulin-like growth factor-1 (IGF-1), formerly known as somatomedin or somatomedin C, has a single chain 70-amino acid polypeptide cross-linked by 3 disulfide bridges. Although IGF-1 provides several benefits similar to insulin such as lower blood sugar levels, the key difference is that insulin mediates mainly a metabolic response, whereas IGF-1 mediates growth-promoting effects (Source)

134 Mutant IDH-targeted therapy and a number of important recent pre-clinical and clinical studies in IDH-mutant solid tumors have been extensively reviewed elsewhere, 147 and listed in Table 2

PMID: 34919824