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This strategy leverages high-expression receptors on BBB endothelial cells to improve targeting efficiency and reduce non-specific distribution (Li and Kataoka, 2021)

doi:10.1023/A:1020621124776

NAD+ is the primary metabolic add-on for KLOW because collagen and tissue remodeling are energy-intensive: repair cells need NAD+ to produce energy, repair DNA, and keep building new tissue