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As we know, chronically high insulin levels trigger the ovaries to over-produce androgen hormones - the leading driver of menstrual cycle issues for women with PCOS

Body Mass and Metabolism: A persons weight and metabolic rate influence how quickly the body processes glutathione

Clinical research on DIM typically uses doses between 100mg and 300mg per day , though the form of DIM matters.30 Standard (crystalline) DIM: Often used at higher doses (e.g., 200300mg) due to lower bioavailability BioResponse DIM (BR-DIM): A more bioavailable form used in many studies, often at doses around 100200mg per day, which may achieve similar effects to higher doses of standard DIM5 That said, higher doses dont necessarily lead to better results

276 Interestingly, accumulation of the BNIP3 paralog BNIP3L/NIX protein not only triggers mitophagy but also activates the mTORC1 pathway