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As a research molecule with limited human safety data, appropriate laboratory procedures should be followed throughout preparation, storage, experimental use, and disposal

Future research should focus on personalized approaches, leveraging advancements in genomics and nanotechnology to refine Se-based therapies

MMP matrix metalloproteinases PKC- protein kinase C isoform MMP-9 expression in vascular endothelial cells is redox sensitive, and the oxidative stress secondary to hyperglycemia provide a rationale to use antioxidants to suppress MMP-9 expression

Furthermore, 3-MA treated fibroblasts expressed higher levels of secreted IL-6 protein in comparison to control cells (Fig