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According to a case report titled "Extremely severe vitamin B12 deficiency case presentation and review of literature", an 83-year-old man reported "paresthesia" in his fingers, among other symptoms including fatigue, vertigo, intolerance of physical activity, upper abdominal pain and loss of appetite

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Methodological heterogeneity across studies using IHC, Western blot, or qPCR can also yield variable Bax/NF-B profiles, with in vivo IHC particularly sensitive to immune cell recruitment