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This applies to both compounds, but it is especially critical for tirzepatide where dose escalation directly impacts GI tolerability

Many people report improved mood, reduced symptoms of depression and anxiety, and better cognitive function after B12 supplementation

In the leukocytes of patients in MOD group, B12-upregulated genes had GO annotations related to phagocytosis, regulation of miRNA transcription, response to virus and monocyte extravasation